In cases of recurrent IVF failures, when there have been two or more unsuccessful IVF attempts, it is advisable to review every aspect again before starting a new treatment.
Especially if pregnancy has not occurred despite the transfer of a good-quality embryo, such as a day-5 embryo (blastocyst-stage embryo), the mother should be re-evaluated thoroughly, and chromosomal tests (genetic tests) should be requested for both parents. Evaluating the uterine cavity, known as the endometrial cavity, through hysteroscopy would be appropriate. Taking a new uterine imaging test to confirm that there is no pathology in the fallopian tubes would also be beneficial.
Additionally, tests related to thyroid function, prolactin levels, diabetes, and coagulation should be performed to ensure that there are no underlying maternal conditions that may prevent embryo implantation. In cases where embryo quality is low, a new treatment should be initiated after quitting smoking, adopting a balanced diet, and addressing any weight-related issues if present.
